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The Epigenome. 

All forms of life, from the simplest single cell species, to the creation of man, have their genetic instructions, seeded within the complex DNA molecular structure.  As science factors in the human genome structure, there has been an enormous undertaking in mapping out, and gaining an understanding of the DNA macromolecule.  With the increase of knowledge, an enigma has surfaced.  The geneticist have discovered, that what they thought was a molecular structure of left over trash, was actually a most necessary component of all life.  That necessary component of life is called an Epigenome. The prefix "epi" in Greek means, "above" or "on top", of the genome, hence Epigenome.  The Epigenome is chemically bonded to the DNA molecule, and is the main conductor that orchestrates the actions of every associated chromosomal gene, within every cell body that influences the living organism, and its structure.  It has now become quite apparent that the Epigenome is the determining element of the matrix of life, that turns all the genes functions, on or off, thereby controlling the genes production of RNA.  RNA (Ribonucleic Acid) is a copy of the gene's DNA instructions that makes the proteins that makes our bodies alive. 

Illustration of DNA spooled around epigenetic markers and histone proteins.


Nature 448, 548-549 (2 August 2007) | doi:10.1038/448548a; Published online 1 August 2007

Era's 1 and 2 were launched by the elucidation of the structure of DNA, and then of the sequence of the human genome. DNA is packaged with histone proteins to form chromatin, the central unit of which is the nucleosomes. As examples of work in the unfolding era 3 the era of the Epigenome the papers of Mikkelsen et al.  and Barski et al. provide genome-wide linear maps relating histone modifications ('marks') to the active or inactive sites where various types of regulatory RNA, as well as messenger RNA, are produced. Nucleosomes are further organized to create open and closed regions of chromatin, which in turn create three-dimensional structures that encompass different levels of gene organization in the chromosomes packed into a cell nucleus. A likely Era 4 will involve generation of maps of this 'genome topography' to reveal how a single genome can produce such a diversity of cell types.

The DNA macromolecule is controlled by the Epigenomes packaged with histone proteins that are within every cell nucleus of that living organism.  Histones with the Epigenome are intelligent spoolers which wind and unwind the DNA macromolecule depending on the Epigenomes' discerned needs of the body of cells. The on off switches of the Epigenomes, dictates to the genes how and when to produce copy strands (transcriptions) of the genes that are called mRNA (messenger ribonucleic acid) and when to shut the process off.  Messenger RNA directs the production of specific amino acids into proteins that are necessary for creation and maintenance of the differentiated cellular tissues and organs of the body. 

Dr. Jean-Pierre Issa says: "The genes that a tissue does not need, or should not express, are specifically turned off by these epigenetic mechanisms, while the other genes that the tissue needs to continue to express are protected from this silencing.  The best example of an epigenetic phenomenon is the face.  Skin, eyes, teeth, and hair all look different, but they contain exactly the same genetic information".  See the film The Epigenome at a Glance by the university of Utah.

This new beginning understanding of the Epigenome, has created a very disturbing counter point in the medical community.  The concept of human disease and illnesses, has completely changed, for it has been determined that the Epigenome is not stagnant, but is influenced through out one's entire lifetime.  The beginning influence is initiated immediately with one's parental inheritance through their parents generational genetic legacy, and then after birth by the environment that we exist in, or create for ourselves.  The on going discovery is that the intelligent Epigenome is changeable in its instructions, because it is influenced by the individual's physical environment, whether good or bad, as well the mental choices in life, whether they are good or bad.  The intelligence of the Epigenome, in and of its self, presents a major problem in the study of the genome of man, for the whole structure of life requires an Intelligence that understands from the beginning, the manifest problems that would be associated with the physical life of the fallen creature.

The human cellular anatomy is an amalgamation of the forces within a corrupt world that influences the natural God given intelligence that is inscribed within the organism.  Within the external environment of this world, the intelligent Epigenome is influenced compositely by environmental radiations of the cosmos, one's choice of foods, drinks, the drugs we take, the cigarettes we smoke, as well as the additional stresses, associated with chemical pollutants emitted into our air, lakes, rivers, oceans, rain and ground water.  The physical and mental stresses are also leveraged within the mitochondrial mutations inherited from the mother. 

So then there is also the internal environment within the human being, where the Epigenome is changed by hormonal productions associated with the processes of an earthly life that only ends in the death of the physical creature.  The stressful thoughts of choosing good, engendering life, and choosing evil, engendering death, are within the spirit of the convoluted mind of man, and are intertwined within the whole of the physical matrix of the body of man kind, and are inscribed on the unseen soul of the person.  The finality of existence is sealed within the soul of a person who chooses The Life of the Creator above all things.

The Lord of Life says: From the abundance of the heart, the mouth speaks. (See Matthew 12 verse 34 and Luke 6 verse 45.) The mouth spews forth the evidence of what is cultivated within the base core of the mindset that is one within the soul of our being. Witness this fact of life: For life and death are in the power of the tongue: and they that love the power of the tongue shall eat the fruit thereof.  (Proverbs 18 verse 21) For the tongue is a fire and a world of iniquity: so the tongue is among our members, for it defiles the whole body, and sets on fire the course of nature; and nature is set on fire by hell. (James 3 verse 6.)

Says Isaiah, whose mouth is left undone in the presence of the Creator of Life: The heart is deceitful above all things, and desperately wicked: who can know it?  What comes out of the mouth gives evidence of the condition of the core heart of a man's thinking, and speaks both the good and the bad, the blessing and curses.  For the tongue can no man tame; it is an unruly evil, full of deadly poison. (Read James 3 verse 1 thru 18.)

However the obscurity of our thoughts are not always exhibited by our verbal speech, but maybe internalized into an anger and bitterness of self-righteousness, and unless moderated by the Love of God, may explode into actions that speak louder than words.   These hostile actions are set in motion by the dark thoughts engendered by the destroyer of life, and affectively bring confusion within the conducting Epigenome of the genetics of man.  The internalized stresses of confused thoughts over the good and the bad choices of life, produces fear of the unknown. and fear has torment.  But when Perfect Love comes, that Love of God cast out all fear, and and we are set at peace within the God of the living, Who saves us from our fears. 

Every one is right in their own eyes,
and as a person thinks in their heart and performs, so they become. 
(See Proverbs 12 verse 15,21:2, and Matthew 12 verse 33 thru 35.)

If one believes in the lies of the enemy of Truth, then they become the lying perversion, and live and promote a life of gross confusion within the dark domain of the Satanic enemy. (See Ephesians 6 verse 11 thru 13.) When the Scriptures speak of the heart of a person, it is referring to the soul's epicenter of their being, where the thoughts of the spirit of the mind would become one with the soul. (See Hebrews 4 verse 12.) The deep thoughts of the spirit of the mind, can change the course of the soul.  If the heart or core of a person's thinking is in darkness, then even within their night dreams, the satanic enemy can continually sow his seeds of corruption within the sleeping mind that is even more vulnerable in Satan's playground of darkness. (See Matthew 13 verse 24 thru 30.) All perversions of sensual thoughts are seeded in man's mind by the prince of death.  That darkness which Satan cultivates within the soil of the self centered mind of man, such as homosexuality, pornography, anger, depression with the allurements to illicit drugs and addictions, will continue to bear the fruits of darkness, becoming evident even in the light of day.  Presently, it is thought that alcoholism is a disease: yes, but the disease is caused by the effects of sin within the human condition.  The very same thing can be said or homosexuality, pornography, anger, or any other sort of abasement of the human kind.

If one perceives they are going in the wrong direction in this life, then think again, and humbly repent and seek God's Wisdom of the Way, and the Truth and the Life in Christ Jesus.  (See Psalm 32 and Proverbs 3 verse 5 thru 7.) Remember, that as one thinks in their heart so they become, whether for good or for evil.   For God shall bring every work into judgment, with every secret thing, whether it be good, or whether it be evil. (Ecclesiastes 12 verse 14.)

Seek the Lord while He may be found, all of you call upon Him while He is near:  Let the wicked forsake his way, and the unrighteous man his thoughts: and let him return unto the Lord, and He will have mercy upon him; and return to our God, for He will abundantly pardon.  For My Thoughts are not your thoughts, neither are your ways My Ways, says the Lord. For as the heavens are higher than the earth, so are My Ways higher than your ways, and My Thoughts than your thoughts. (Isaiah 55 verse 6 thru 9.)

If, in this environment of life on earth, the instructions of the Epigenome are changeable, then it is certainly possible for wrong thoughts and choice of actions to make an impact upon our body and mind for evil.  As the primary example, fear, has torment and reeks havoc upon the mind and then the body. Conversely, good  thoughts and right actions can begin to change the wrong into the good that God desires for a child to exercise. (See Philippians 4 verse 8.) There is no fear in Love/Agape but Perfect Love casts out fear: He that fears is not made perfect in Love. (1st John 4 verse 18.)  For God so Loved/Agaped the world that He sent His only begotten Son of Perfect Love into this dark world, so that whosoever believes in Him should not perish, but have everlasting Life.  Therefore be not conformed to this world: but be you transformed by the renewing of your mind, that you may prove what is that good, and acceptable, and the Perfect Will of God. (Romans 12 verse 2.)

The Epigenome possesses electro chemical memory of the past and the present, and the essence of those memories are not erased in the parents production of eggs or sperm, wherein the good or the bad of genetics, may be expressed immediately, or as child progresses with age.  Today is the time to begin the necessary disciplines of faith in the Word of God, and practice those good things that promote life, and change that which is possible.  For we can do all things through Christ, Who strengthens us. (Philippians 4 verse 13.) So then put off concerning the former conversation the old man, which is corrupt according to the deceitful lusts; And be renewed in the spirit of your mind; So that you put on the new man, [the new creation] which after God is created in righteousness and true holiness. (Ephesians 4 verse 22 thru 24.)

To proceed to the next chapter please click on  The First Adam.

 

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Robert Glenn Pratten